OEM China 1950/7/7 - Atracurium besylate 64228-81-5 Anaesthetic – Neore
OEM China 1950/7/7 - Atracurium besylate 64228-81-5 Anaesthetic – Neore Detail:
Payment: T/T, L/C
Product Origin: China
Shipping Port: Beijing/Shanghai/Hangzhou
Production capacity: 50kg/month
Order(MOQ): 25kg
Lead Time: 3 Working Days
Storage condition: Preserve in tight, light-resistant containers, in a cold place.
Package material:drum
Package size:25kg/drum
Safety information: Not dangerous goods
Introduction
Atracurium besylate, is a medication used in addition to other medications to provide skeletal muscle relaxation during surgery or mechanical ventilation. It can also be used to help with endotracheal intubation but suxamethonium (succinylcholine) is generally preferred if this needs to be done quickly. It is given by injection into a vein. Effects are greatest at about 4 minutes and last for up to an hour.
Common side effects include flushing of the skin and low blood pressure. Serious side effects may include allergic reactions; however, it has not been associated with malignant hyperthermia. Prolonged paralysis may occur in people with conditions like myasthenia gravis. Atracurium is a medication used in addition to other medications in to provide skeletal muscle relaxation during surgery or mechanical ventilation. It can be used to help with endotracheal intubation but takes up to 2.5 minutes to result in appropriate intubating conditions.
Specification (USP40)
|
Item |
Specification |
| Identification | IR
The retention times of the three main isomeric pearks of the sample solution correspond to those of the Stanrdard solution, as obtained in the assay |
| Related substances | Impurity E NMT1.5%
Impurity F: NMT 1.0% Impurity G: NMT 1.0% Impurity D: NMT 1.5% Impurity A: NMT 1.5% Impurity I: NMT 1.0% Impurity H: NMT 1.0% Impurity K: NMT 1.0% Impurity B: NMT 0.1% Impurity C: NMT 1.0% Any other impurity: NMT0.1% Total Impurities: NMT3.5% |
| Impurity J | NMT 100PPM |
| Isomer composition | Atracurium cis-cis isomer: 55.0%-60.0%
Atracurium Cis-trans isomer: 34.5%-38.5% Atracurium Trans-trans isomer: 5.0%–6.5% |
| Water | NMT 5.0% |
| Residual Solvents | Dichloromethane: NMT 600ppm
Acetonitrile: NMT 410ppm Ethyl Ether: NMT 5000ppm Toluene: NMT 890ppm Acetone: NMT 5000ppm |
| Residue on Ignition | NMT 0.2% |
| Assay | 96.0-102.0% (Anhydrous substance) |
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