Factory supplied Magnesium Ascorbyl Phosphate - Tacrolimus monohydrate 109581-93-3 Antibiotic – Neore
Factory supplied Magnesium Ascorbyl Phosphate - Tacrolimus monohydrate 109581-93-3 Antibiotic – Neore Detail:
Payment: T/T, L/C
Product Origin: China
Shipping Port: Beijing/Shanghai/Hangzhou
Production capacity: 1kg/month
Order(MOQ): 1g
Lead Time: 3 Working Days
Storage condition: Stored in cool, dry place, room temperature.
Package material: vial, bottle
Package size: 1g/vial, 5/vial, 10g/vial, 50g/bottle, 500g/bottle
Safety information: UN 2811 6.1/PG 3
Introduction
Tacrolimus, is an immunosuppressive drug. After allogeneic organ transplant, the risk of organ rejection is moderate. To lower the risk of organ rejection, tacrolimus is given. The drug can also be sold as a topical medication in the treatment of T-cell-mediated diseases such as eczema and psoriasis. It can be used to treat dry eye syndrome in cats and dogs.
Tacrolimus inhibits calcineurin, which is involved in the production of interleukin-2, a molecule that promotes the development and proliferation of T cells, as part of the body’s learned (or adaptive) immune response.
Specification (USP43)
|
Item |
Specification |
|
Appearance |
White or almost white crystalline powder |
|
Identification |
IR, HPLC |
| Solubility |
Very soluble in methanol, freely soluble in N,N dimethylformamide and in alcohol, practically in soluble in water. |
|
Residue on ignition |
≤0.10 % |
|
Organic impurities (procedure-2) |
Ascomycin 19-epimer ≤0.10 % |
|
Ascomycin ≤0.50 % |
|
|
Desmethyl tacrolimus ≤0.10 % |
|
|
Tacrolimus 8-epimer ≤0.15 % |
|
|
Tacrolimus 8-propyl analog ≤0.15 % |
|
|
Unknown impurity -I ≤0.10 % |
|
|
Unknown impurity -II ≤0.10 % |
|
|
Unknown impurity -III ≤0.10 % |
|
|
Total impurities ≤1.00 % |
|
|
Optical rotation (on as is basis) (10mg/ml in N,Ndimethylformamide) |
-110.0° ~ -115.0° |
|
Water content (by KF) |
≤4.0% |
|
Residual solvents (by GC) |
Acetone ≤1000ppm (In-house) |
|
Di-isopropyl ether ≤100ppm (In-house) |
|
|
Ethyl ether ≤5000ppm |
|
|
Acetonitrile ≤410ppm |
|
|
Toluene ≤890ppm |
|
|
Hexane ≤290ppm |
|
|
Microbial test (in house) |
Total aerobic microbial count ≤100cfu/gm |
|
Total yeast and mould count ≤10cfu/gm |
|
|
Specified organisms (Pathogens) (E.coil, salmonella sps., S.aureus. Pseudomonas aeruginosa) should absent |
|
|
Assay (by HPLC) (on anhydrous and solvent free basis) |
98%~102% |
Product detail pictures:
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Assume full accountability to fulfill all demands of our purchasers; attain continual advancements by marketing the advancement of our clientele; grow to be the final permanent cooperative partner of purchasers and maximize the interests of purchasers for Factory supplied Magnesium Ascorbyl Phosphate - Tacrolimus monohydrate 109581-93-3 Antibiotic – Neore , The product will supply to all over the world, such as: Malta, Canberra, Bangalore, We have more than 100 works in the plant, and we also have a 15 guys work team to service our customers for before and after sales. Good quality is the key factor for the company to stand out from other competitors. Seeing is Believing, want more information? Just trial on its products!
By Mona from Montpellier - 2018.05.13 17:00
We are long-term partners, there is no disappointment every time, we hope to maintain this friendship later!
By Eileen from New Zealand - 2018.11.02 11:11
