2022 High quality Vardenafil HCL Trihydrate - Orlistat 96829-58-2 Antiobesity Diet supplement – Neore
2022 High quality Vardenafil HCL Trihydrate - Orlistat 96829-58-2 Antiobesity Diet supplement – Neore Detail:
Payment: T/T, L/C
Product Origin: China
Shipping Port: Beijing/Shanghai/Hangzhou
Production capacity: 800kg/month
Order(MOQ): 25kg
Lead Time: 3 Working Days
Storage condition: Stored in cool, dry place, room temperature.
Package material: drum
Package size: 25kg/drum
Safety information: Not dangerous goods
Introduction
Orlistat is a long-acting and powerful specific gastrointestinal lipase inhibitor. It is white or nearly white powder at room temperature, which insoluble in water, soluble in chloroform, and easily soluble in ethanol. It inactivates the enzyme by forming covalent bonds with the active serine sites of gastric lipase and pancreatic lipase in the stomach and small intestine.
Orlistat is a kind of lipase inhibitor weight-loss drug. It is a hydrated derivative of lipstatin, which can reduce the absorption of food fat and reduce weight. This product has strong and selective inhibition of gastric lipase and pancreatic lipase, has no effect on other digestive enzymes (amylase, trypsin, chymotrypsin) and phospholipase, and does not affect the absorption of carbohydrates, proteins and phospholipids. It inactivates the enzyme mainly through covalent binding with serine residues at the active sites of gastric lipase and pancreatic lipase in the gastrointestinal tract, inhibits the hydrolysis of triacylglycerol, reduces the intake of monoglyceride and free fatty acid, and thus controls body weight. The drug is not absorbed by gastrointestinal tract, and the inhibition of lipase is reversible.
This product also has the function of regulating blood lipids. It can reduce triglyceride and low-density lipoprotein cholesterol in the serum of obese patients and increase the ratio of high-density lipoprotein to low-density lipoprotein.
When orlistat combined with a low calorie diet, it is suitable for the long-term treatment of obese and overweight people, including those who have developed obesity related risk factors. It has long term weight control function such as weight loss, weight maintenance and rebound prevention. The clinical shows obviously that the weight control function is very useful for long term usage when company with meal or after one hour of meal.
Orlistat can reduce the incidence rate of obesity related risk factors and other obesity related diseases, including hypercholesterolemia, type II diabetes, impaired glucose tolerance, hyperinsulinemia, hypertension, and reduce the fat content in organs.
Specification (USP42)
|
Item |
Specification |
|
Identification |
HPLC, IR |
| Specific optical rotation | -48.0°~-51.0° |
| Water content | ≤0.2% |
| Related substances I | Orlistat related compound A ≤0.2% |
| Related substances II | Orlistat related compound B ≤0.05% |
| Related substances III
|
Formylleucine ≤0.2% |
|
Orlistat related compound C ≤0.05% |
|
|
Orlistat open ring epimer ≤0.2% |
|
|
D-Leucine orlistat ≤0.2% |
|
|
Individual unidentified impurity ≤0.1% |
|
| Related substances IV |
Orlistat related compound D ≤0.2% |
|
Orlistat open ring amide ≤0.1% |
|
| Related substances V |
Orlistat related compound E ≤0.2% |
| Total impurities (I to V) |
≤1.0% |
| Residual solvents |
Methanol ≤0.3% |
|
EtOAc ≤0.5% |
|
|
n-Heptane ≤0.5% |
|
| Residue on ignition |
≤0.1% |
| Heavy metals as Pb |
≤20ppm |
| Assay by HPLC |
98.0%~101.5% (on anhydrous, solvent-free basis) |
Product detail pictures:
Related Product Guide:
We are commitment to offer you the aggressive price tag ,exceptional products and solutions high-quality, as well as fast delivery for 2022 High quality Vardenafil HCL Trihydrate - Orlistat 96829-58-2 Antiobesity Diet supplement – Neore , The product will supply to all over the world, such as: Turkey, Romania, Malaysia, With the development and enlargement of mass clients abroad, now we have set up cooperative relationships with many major brands. We have our own factory and also have many reliable and well-cooperated factories in the field. Adhering to the "quality first, customer first, We are provideing high-quality, low-cost products and first-class service to customers. We sincerely hope to establish business relationship with customers from all over the world on the basis of quality, mutually benefit. We welcome OEM projects and designs.
By Paula from Saudi Arabia - 2017.03.08 14:45
The customer service staff's attitude is very sincere and the reply is timely and very detailed, this is very helpful for our deal,thank you.
By Marina from Chicago - 2018.12.22 12:52
